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The Master
The Master, or Missy, is a renegade alien Time Lord and the childhood friend and later archenemy of the Doctor. He is a brilliant scientist and manipulator, and his plans for galactic domination have always been thwarted by the Doctor. He has been played by many actors over the years, including Roger Delgado, Peter Pratt, Geoffrey Beevers, Anthony Ainley, Eric Roberts, Derek Jacobi, John Simm, Michelle Gomez, and Sacha Dhawan.